Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis.

Nat Commun · 2026 · PMC13066379 · PMID 41771860

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showed a trendno p-value reported

TCA cycle intermediates such as alpha-ketoglutarate (α-KG) and succinate showed a trend of reduction in BCKA-treated β-cells (Supplementary Fig. 16c ).

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