Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease.

This model yielded a highly significant association to AD (ACAT-O CON p = 2.21 × 10 −52 ; p Lassosum _CON = 1.1 × 10 −52 ; z Lassosum = 9.94; R 2 Lassosum = 5.7%).

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Finally, we restricted our associations to genes where there was at least a nominally significant p-value (p < 0.01) for a minimum of two out of five methods tested (in addition to a Bonferroni-corrected significant ACAT-O CON p-value) ( Figure 1 ).

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However, when both variables were included within the model, only the SPI1 locus association remained significant ( z = −2.73, p = 0.006), while the MYBPC3 genetically-regulated expression association was no longer marginally significant ( z = −0.66, p = 0.51).

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