Improving small brain metastasis detection with composite and augmented T<sub>1</sub>-weighted imaging in contrast-enhanced multi-parametric MRI.

Further, a significant interaction effect between structure and imaging type (F [2, 28] =8.26, P=0.006) was observed, with post-hoc comparisons suggesting that the CNR gain in MULTIPLEX-aT 1 W imaging relative to MPRAGE-T 1 W imaging was mainly driven by the improvement in lesion-to-GM contrast (t [29] =5.87, P<0.001, FWE, Cohen’d =1.52), while the lesion-to-WM contrast difference did not reach statistical significance (t [14] =2.42, P=0.088, FWE, Cohen’d =0.63; Figure 5C ).

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