Multimodal Imaging Investigation of the Dentato-Thalamo-Cortical Pathway in Friedreich's Ataxia.

Mov Disord · 2026 · PMC13067320 · PMID 41566916

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an elevated trendno p-value reported

Particularly, in addition to atrophy, lower ATP levels and an elevated trend of the NAD(H) levels were observed in the bilateral dentate regions in FRDA patients compared to controls.

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did not reach statistical significanceno p-value reported

Although phospholipid membrane metabolism changes did not reach statistical significance, these changes may reflect imbalanced phospholipid membrane turnover, presuming impaired cell membrane reparation and myelin damage in the dentate nucleus in the early stage of FRDA. 51 In contrast, in the bilateral thalami and left motor cortex, we found only enhanced breakdown of cell membranes.

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