For treatment-related mortality, the point estimate favored a higher risk after CAR-T therapy, but the pooled effect did not reach statistical significance (RR 1.60; 95% CI, 0.96–2.65), likely due to limited event counts, heterogeneous definitions, and insufficient power to detect modest differences.
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Toxicities associated with CAR-T therapy compared with standard treatments in hematologic malignancies: a systematic review and meta-analysis.
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