Therefore, our findings that stochastic nanoroughness (nanotopography) can induce the spontaneous association of naïve astrocyte into spheroids, and induce transcription traits observed in proneural GBM are quite significant as they provide evidence for a potential biophysical basis for the formation of glioma; and a plausible mechanism to underpin the cause‐and‐effect link between TBI and GBM.
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Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma-Like Transcriptional Programs in Astrocytes.
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