Integrating baseline ctDNA-derived tumor metrics enhances risk stratification in HR-positive/HER2-negative advanced breast cancer: a real-world multicenter cohort study from Austria.

ESMO Open · 2026 · PMC13068563 · PMID 41922145

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

did not reach statistical significanceP = 0.058so close (0.05 < p ≤ 0.1)

Overall TFx was low (median z-score 2.49; range −0.5-208.3), with higher levels in 2L, although the difference did not reach statistical significance ( P = 0.058).

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