Daily biomarker trajectories predict major bleeding in patients on venovenous ECMO for ARDS: a retrospective longitudinal cohort study.

Sci Rep · 2026 · PMC13069085 · PMID 41957100

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showed a trendp = 0.069so close (0.05 < p ≤ 0.1)

State-transition analysis Sensitivity GLMMs with nested random intercepts confirmed the Markov findings: the post-exchange phase was associated with reduced odds of incident bleeding (OR 0.14, 95% CI 0.029–0.67, p = 0.014) and showed a trend toward reduced bleeding persistence (OR 0.18, 95% CI 0.028–1.14, p = 0.069).

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