High-fat diet attenuates estradiol's efficacy on cognitive function and hippocampal synaptic plasticity in middle-aged ovariectomized mice.

In the test phase, only the low‐fat diet‐fed estradiol‐treated group showed significant difference from chance (0.5) ( t (13) = 3.8; p = 0.002), while the high‐fat diet estradiol‐treated group showed a trend ( t (12) = 1.84; p = 0.090).

also in 53,322 other papers

Simple effects tests showed that estradiol‐treated mice in the high‐fat‐fed groups weighed significantly less compared with their respective vehicle‐treated controls (HFD‐E2 VS HFD‐VEH F (1, 18) = 20.03, p < 0.0003, η p 2 = 0.53); there was a nonsignificant trend of lower magnitude in the low‐fat diet‐fed group (LFD‐E2 vs.

also in 5,406 other papers