Blood volume-sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.

In CA1, the imaging contrast x depth interaction was highly significant (β = -0.005, p = 0.0005), demonstrating that the depth-dependent slope for VASO differed markedly from that of BOLD.

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All other pairwise comparisons did not reach statistical significance.

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Similarly, laminar profiles of tSNR were consistently larger for BOLD than for VASO and remained relatively constant across subfields’ depths, with the exception of the subiculum displaying an increasing trend in tSNR from SRLM toward the inner surface ( Fig. 8 ).

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