Integrated network pharmacology and metabolomics to analyze the mechanism of Shaofu Zhuyu Decoction in treatment of dysmenorrhea of cold coagulation and blood stasis.

By comparing the concentration of different metabolites, it was found that among the 12 different metabolites screened, six of the differential metabolites (LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0), LysoPC(0:0/20:4(5Z,8Z,11Z,14Z), LysoPC(20:3(8Z,11Z,14Z)/0:0), 1- O -Hexadecyl- sn -glycero-3-phosphocholine, LysoPC(p-18:0/0:0), SM(d18:1/16:0)) showed an overall tendency to return to normal, with significant callbacks in the QF group ( P < 0.05), HX group and WJ group also showed a trend of correction.

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