Local FLASH radiation exhibits a double-edged effect on the mouse immune system.

Radiat Oncol · 2026 · PMC13069716 · PMID 41782029

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closest p · 1.2× alpha

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barely significantp = 0.06so close (0.05 < p ≤ 0.1)

Consistently, an F-test showed that the dose response curves for 2 different dose rates were significantly different for naïve CD4 + and naïve CD8 + subsets, and barely significant( p = 0.06) for CD3 + and CD8+ (Supplementary Table 5 ).

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showed a trendno p-value reported

Cytokine and chemokine changes in circulating blood Overall, cytokines and chemokines showed a trend of increase on both days 1 and 4 post-irradiation, especially on day 4 after high-dose irradiation (15 Gy and 20 Gy) at relative low dose rate (10 Gy/s) (Fig. 8 A).

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