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EREG-secreting THBS1<sup>+</sup> tissue monocytes are recruited by C5a to promote rapid liver regeneration in patients and mice during the ALPPS procedure.

Hepatobiliary Surg Nutr · 2026 · PMC13071667 · PMID 41983196

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Compared with ALPPS stage I, there was a trend toward an increase in monocytes (from 30.80% to 40.12%) and a decrease in NK cells (from 18.69% to 13.51%) and DCs (from 1.62% to 0.94%) in stage II, although these differences failed to reach statistical significance ( Figure 1G and Figure S3D ).

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