Although patients with a higher stromal proportion exhibited a trend toward a lower OS rate, the difference did not reach statistical significance (P=0.13; Figure S2D ).
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NOTCH4 as a driver of epithelial-mesenchymal transition, angiogenesis, and stromal remodeling in lung adenocarcinoma: integrated transcriptomic and protein-level validation.
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Nevertheless, the HR of 1.617 in the multivariate analysis indicates a notable trend toward increased risk, and its significant univariate P values suggest that NOTCH4 remains a clinically relevant indicator of tumor aggressiveness.