Barely Significant
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NOTCH4 as a driver of epithelial-mesenchymal transition, angiogenesis, and stromal remodeling in lung adenocarcinoma: integrated transcriptomic and protein-level validation.

Transl Lung Cancer Res · 2026 · PMC13071774 · PMID 41982690

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hedged sentences
0.1300
closest p · 2.6× alpha
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boldest claim

The sentences

Although patients with a higher stromal proportion exhibited a trend toward a lower OS rate, the difference did not reach statistical significance (P=0.13; Figure S2D ).

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a notable trendno p-value reported
Nevertheless, the HR of 1.617 in the multivariate analysis indicates a notable trend toward increased risk, and its significant univariate P values suggest that NOTCH4 remains a clinically relevant indicator of tumor aggressiveness.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.