Design, Synthesis, and Biological Evaluation of Novel Vinyl Selenone Derivatives as Potent Nrf2 Activators for Atopic Dermatitis.

J Med Chem · 2026 · PMC13071876 · PMID 41805335

Europe PMC DOI

hedged sentences

0.0662

closest p · 1.3× alpha

0.0662

boldest claim

The sentences

near-significantp = 0.0662so close (0.05 < p ≤ 0.1)

As expected, 5w decreased mast cell counts in a concentration-dependent manner, with a near-significant reduction in the 0.1% group ( p = 0.0662) and a significant reduction in the 0.5% group ( Figure D,E).

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a nonsignificant trendno p-value reported

Dexamethasone treatment showed only a nonsignificant trend toward recovery.

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