Dissecting Sex Chromosome and Hormonal Contributions to Urethane-Induced Lung Tumorigenesis Using the Four Core Genotypes Mouse Model.

Cancers (Basel) · 2026 · PMC13072358 · PMID 41976394

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.5983

boldest claim

The sentences

narrowly missed statistical significancep = 0.051so close (0.05 < p ≤ 0.1)

A similar magnitude difference was observed between XYF and XYM animals (Difference = 98.8 ± 35.5), although this comparison narrowly missed statistical significance after Tukey adjustment ( p = 0.051).

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did not reach statistical significancep = 0.5983not close (p > 0.1)

Within-genotype comparisons indicated higher lung weights in urethane-treated mice relative to PBS controls in XXM ( p = 0.0457), XYF ( p = 0.0116), and XYM ( p = 0.0235), whereas the increase in XXF did not reach statistical significance ( p = 0.5983) ( Figure 2 A).

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