Utilities of next-generation sequencing in the surgical management of thyroid nodules in China.

BMC Endocr Disord · 2026 · PMC13072540 · PMID 41787459

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Cytological diagnosis from FNA samples typically follows the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), categorizing nodules into clearly benign (Bethesda II) and malignant (Bethesda VI), as well as categories with indeterminate significance, notably Bethesda III (atypia of undetermined significance [AUS]) and Bethesda IV (follicular neoplasm [FN]) [ 4 , 5 ].

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