Hepatocyte PPARα Is Essential for Triglyceride-Lowering Effect of Pemafibrate.

Int J Mol Sci · 2026 · PMC13072797 · PMID 41977487

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

For Cpt1a (carnitine palmitoyl-CoA transferase 1a) and Acadvl (very-long-chain acyl-CoA dehydrogenase, VLCAD), the interaction terms did not reach statistical significance ( p = 0.09 and 0.06, respectively), although PEM tended to induce higher expression preferentially in Ppara fl/fl mice.

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