C-Reactive Protein Trajectories by Summary Metric Across the Coronavirus-2019 Period: A 16-Year Interrupted Time-Series Analysis (2008-2023).

Diagnostics (Basel) · 2026 · PMC13073204 · PMID 41975792

Europe PMC DOI

hedged sentence

0.0409

closest p · 0.8× alpha

0.0409

boldest claim

The sentences

nominally significantp = 0.0409actually significant

For the post-2020 slope-change term (β 3 ), the arithmetic mean result remained significant after Bonferroni correction (adjusted p = 0.0165), whereas the harmonic mean result, although nominally significant in the unadjusted analysis (raw p = 0.0409), no longer met the corrected significance threshold (Bonferroni-adjusted p = 0.1227; BH-adjusted p = 0.0614).

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