Growth Differentiation Factor 15 as a Biomarker of Cardiovascular Burden and Mortality in a Population-Based Cohort.

Int J Mol Sci · 2026 · PMC13073294 · PMID 41977265

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

borderline significancep = 0.051so close (0.05 < p ≤ 0.1)

However, after the inclusion of NT-proBNP (Model B), the association of GDF15 with all-cause mortality was attenuated, reaching borderline significance (HR 2.61; 95% CI: (0.99–6.87), p = 0.051), whereas NT-proBNP retained significance (HR 1.11; 95% CI: (1–1.22), p = 0.044) ( Table S2 ). 2.4.

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did not reach statistical significancep = 0.052so close (0.05 < p ≤ 0.1)

In contrast, when NT-proBNP was added to the base model (Model C), the C-index increased only marginally from 0.879 to 0.880 (ΔC-index = +0.001), and the improvement in model fit did not reach statistical significance (χ 2 = 3.76, p = 0.052).

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