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Role of the Glycine Transporter GlyT2 in the Neuronal Differentiation of PC12 Cells.

Int J Mol Sci · 2026 · PMC13073545 · PMID 41977215

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While this reduction did not reach statistical significance in parental or GlyT1-expressing cells, GlyT2-expressing clones displayed a significant 38% decrease in ERK phosphorylation under basal conditions, highlighting the particular sensitivity of GlyT2-mediated differentiation to calcium availability.

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