The Prognostic Effect of Sarcopenia in Solid Cancers Treated with Immunotherapy: A Systematic Review and Meta-Analysis.

J Clin Med · 2026 · PMC13073668 · PMID 41977025

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0540

boldest claim

The sentences

showed a trendp = 0.051so close (0.05 < p ≤ 0.1)

The studies with patients receiving immunotherapy as a second-line treatment or beyond showed a trend towards a significant overall effect (HR = 1.38; p = 0.051) ( Figure S1B ); heterogeneity was high in these studies (Chi 2 = 39.48; p < 0.001; I 2 = 80%). 3.6.

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a trend towards significancep = 0.054so close (0.05 < p ≤ 0.1)

All showed a significant test for overall effect, except for the gastric cancer (GC) subset which did show a trend towards significance ( p = 0.054).

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