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Clinical and Hemodynamic Effects of Pulmonary Artery Denervation in Pulmonary Hypertension Despite Optimized Pharmacotherapy: An Updated Systematic Review and Meta-Analysis.

J Clin Med · 2026 · PMC13073870 · PMID 41976921

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Although a trend toward improvement in TAPSE was observed, the effect did not reach statistical significance, suggesting limited sensitivity of TAPSE as a marker of PADN-related RV functional changes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.