Impact of SGLT2 Inhibitors on Multiple Cardiometabolic Risk Factors: A Retrospective Cohort Study.

J Clin Med · 2026 · PMC13074018 · PMID 41976851

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0770

boldest claim

The sentences

did not reach statistical significancep = 0.070so close (0.05 < p ≤ 0.1)

The independent effect on diastolic blood pressure did not reach statistical significance (β = 4.97, 95% CI: −0.41 to 10.35, p = 0.070) ( Table 6 ). 4.

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borderline significancep = 0.077so close (0.05 < p ≤ 0.1)

In the primary multivariable model, using absolute HbA1c change as the outcome and adjusting for baseline HbA1c, age, sex, insulin, biguanide, and DPP4i use, the SGLT2I treatment effect showed borderline significance (β = 0.253, 95% CI: −0.03 to 0.53, p = 0.077).

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a favorable trendno p-value reported

While this finding may suggest a favorable trend in renal function, it should be interpreted with caution given the retrospective design and relatively short follow-up period.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.