Optimization of Extraction Process for Flavonoids from <i>Sonchus oleraceus</i> L. and Evaluation of Anti-Inflammatory Activity of Luteoloside.

c regression multivariate equation was established as follows: Y = 21.25 + 0.798333A − 0.0258333B + 1.13333C + 1.06917D + 0.8125AB − 1.035AC − 0.3475AD − 0.2375BC − 0.0025BD − 0.7075CD − 1.19292A 2 − 2.25417B 2 − 2.72792C 2 − 1.05417D 2 As shown in Table 2 , the model exhibited a p -value < 0.0001 (highly significant), while the lack-of-fit term had a p -value of 0.5375 (not significant).

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With increasing ethanol concentration, the extraction yield showed a trend of first increasing and then decreasing.

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