Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.

Front Neurosci · 2026 · PMC13076293 · PMID 41987925

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closest p · 0.0× alpha

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highly significantp < 0.001actually significant

Cochran’s Q test was highly significant for bilirubin ( Q = 44,447; df = 20; p < 0.001), infection ( Q = 77.5, df = 19, p < 0.001) and “other” ( Q = 69.91, df = 11, p < 0.001) demonstrating that the observed variation in effect sizes exceeds that expected by chance alone and the I 2 statistic approached 100% (bilirubin), 81% (infection), 97% (other).

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did not reach statistical significanceno p-value reported

3.3.3 Risk of hearing loss relative to TSB concentration While the association between TSB and hearing loss did not reach statistical significance for the eight studies included in the estimate, the direction and magnitude of effect were consistent with related bilirubin biomarkers, suggesting a potentially meaningful biological signal.

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