Chemotherapy driven alterations in NK cell receptors and ligands in high grade serous ovarian cancer.

Moreover, the expression of these receptors (NKp30, p = 0.05, NKp44, p = 0.042, NKp46, p = 0.0211) was also increased in chemotherapy treated surgical cohort compared with chemotherapy naïve cohort ( Figure 4A ) KIR2DL2/L3/S3+CD3-CD56 + Dim NK cells were also comparable to the healthy control levels in chemotherapy treated cohort and showed a trend towards higher expression compared with the chemotherapy naïve surgical cohort ( Figure 4B ), which indicates comprehensible chemotherapy-mediated immune modulation of CD3-CD56 + Dim NK cell in peripheral blood.

also in 53,322 other papers