Angiography-derived assessment of coronary microcirculatory resistance in patients with chronic total occlusion.

Heart Vessels · 2026 · PMC13076405 · PMID 41249707

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highly significantno p-value reported

In addition, we observed that successful CTO-PCI led to a highly significant improvement in both CCS and NYHA class, and that this clinical benefit occurred independently of the presence of CMD (no difference in CCS or NYHA improvement between IMR > 25 and ≤ 25).

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did not reach statistical significanceno p-value reported

The decrease reached statistical significance in RCA CTOs only (Δ IMR: 3.1 ± 6.4; p = 0.0246), while reductions in LAD (Δ IMR: 2.7 ± 7.0; p = 0.283) and LCX (Δ IMR: 3.6 ± 7.5; p = 0.053) were of similar magnitude but did not reach statistical significance, likely reflecting smaller sample sizes in these subgroups.

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