Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study.

Nutr J · 2026 · PMC13077837 · PMID 41787523

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failed to reach statistical significanceno p-value reported

CTX-II concentration At the end of the study the urinary concentration of CTX-II decreased 5.7% (-19.87 ± 24.67 ng/mmol Cr) in the CN2 group and increased 7.4% (24.93 ± 22.54 ng/mmol Cr) in the PBO group as compared to baseline, but differences failed to reach statistical significance in the general population.

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