Epimutations in migraine and in medication overuse headache: a longitudinal study after acute medication withdrawal.

J Headache Pain · 2026 · PMC13077941 · PMID 41896723

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0850

boldest claim

The sentences

did not reach statistical significancep = 0.058so close (0.05 < p ≤ 0.1)

While differences among HC, and EM_noOveruse, HC and Chronic_noOveruse did not reach statistical significance, a consistent trend of increasing numbers of new SEMs from HC to EM_noOveruse to Chronic_noOveruse was observed (both p = 0.058).

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a trend toward significancep = 0.085so close (0.05 < p ≤ 0.1)

However, after multiple testing correction, this comparison did not reach statistical significance, showing only a trend toward significance ( p = 0.085).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.