Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesis.

The single-PHD mKO mice did not show increased HIF1α and HIF2α stability or elevated levels of classical HIFα target gene expression in skeletal muscles, although PHD1 deficiency tended to lead to increased HIFα protein levels that did not reach statistical significance, and no corresponding increase in target gene expression was observed ( Supplemental Figure 2 , D and E), suggesting that depletion of a single PHD alone is insufficient to stabilize HIFα.

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