ATP and major affective disorders: the involvement of P2X receptors in pathophysiology.

Purinergic Signal · 2026 · PMC13079264 · PMID 41979804

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But the gene set enrichment analysis performed on the summary statistics of the polygenic risk score (PRS) computed with 6.7 million SNPs spread over the whole genome (pathway-based polygenic risk score analysis) derived from the multi-ancestry BD sample identified several genetic pathways containing purinergic receptor genes that showed a trend of association with BD ( P -values close to GWAS significance ( P = 0.05 _8 ).

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