Characteristics and outcomes of patients treated with tigecycline for MDR gram-negative infections: a retrospective cohort study.

Front Cell Infect Microbiol · 2026 · PMC13079584 · PMID 41994202

Europe PMC DOI

hedged sentences

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

a nonsignificant trendp = 0.066so close (0.05 < p ≤ 0.1)

Early tigecycline start demonstrated a nonsignificant trend toward lower mortality (OR 0.64; 95% CI, 0.40–1.03; p = 0.066), but no other covariates approached the predefined threshold for inclusion based solely on univariate significance.

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did not reach statistical significanceno p-value reported

The clinical success remained numerically higher with monotherapy but did not reach statistical significance, further supporting the notion that the observed differences in the overall cohort were driven by confounding by indication.

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