Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5.

In addition, treatment with the ferroptosis inhibitor Ferr-1 29 , 30 partially rescued the hyaloid vascular abnormalities in aldh3b1 -/- and in 2-HD treated larvae, although the effect on vascular sprouts in 2-HD–treated larvae did not reach statistical significance (Fig. 5N, O ), conclusively implicating ferroptosis as the critical mechanism behind these phenotypes in both aldh3b1 -/- and in 2-HD treated zebrafish.

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