The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross-Sectional Study.

Mediators Inflamm · 2026 · PMC13082362 · PMID 41984524

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did not reach statistical significanceno p-value reported

Notably, below the inflection point (ln AISI = 4.34), the negative estimate did not reach statistical significance and had a wide confidence interval; therefore, this finding requires confirmation in future longitudinal studies.

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