Barely Significant
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Metformin and butyrate attenuate chronic radiation proctitis by alleviating inflammation and macrophage senescence.

Front Immunol · 2026 · PMC13083195 · PMID 42004949

Europe PMCDOI
2
hedged sentences
0.0568
closest p · 1.1× alpha
0.0568
boldest claim

The sentences

did not reach statistical significancep = 0.0568so close (0.05 < p ≤ 0.1)
Although p16 expression did not reach statistical significance compared with irradiated controls (p = 0.0568), MeBu treatment produced a downward trend, with expression levels comparable to those in non-irradiated cells ( Figure 6a ).

also in 111,027 other papers

may be significantno p-value reported
The synergistic effects of MeBu may be significant by four primary mechanisms: anti-inflammatory action, senescence modulation, tight junction restoration, and epigenetic regulations.

also in 13,097 other papers

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