Barely Significant
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Evaluation of lidocaine as a dual-route prophylaxis in postoperative catheter-related bladder discomfort: a comprehensive systematic review and meta-analysis with trial sequential analysis and GRADE evaluation.

Naunyn Schmiedebergs Arch Pharmacol · 2026 · PMC13086742 · PMID 41533159

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The overall pooled estimate did not reach statistical significance, which can be attributed to significant heterogeneity and the varying potency of the opioids analyzed (tramadol, fentanyl, morphine).

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