[3-<sup>11</sup>C]Pyruvate PET detects alterations in cardiac pyruvate metabolism induced by doxorubicin chemotherapy.

In addition, the bicarbonate/lactate ratio was reduced by approximately 33% for the mice from the DOX group, although this difference did not reach statistical significance with our group size ( p = 0.0713; Fig. 3f ).

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Differences in transit time, which represents the area under the TAC, did not quite reach statistical significance due to 2 mice in the control group whose τ was greater than 350 s (versus a mean value for the remaining 7 mice of 298 s).

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