An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.

Schizophrenia (Heidelb) · 2026 · PMC13087269 · PMID 41792186

Europe PMC DOI

hedged sentences

0.0327

closest p · 0.7× alpha

0.0799

boldest claim

The sentences

modestly significantp = 0.0327actually significant

Meta-analysis between global fractional anisotropy (gFA) and positive symptoms A random effects meta-analysis was conducted using the site-specific correlation coefficients for the association between gFA and positive symptoms ( n = 1025), which indicated a modestly significant negative association between gFA and positive symptoms across all 19 sites ( r = −0.0686 [−0.1303, −0.0063], p = 0.0327, df = 18).

also in 257 other papers

showed a trendp = 0.0799so close (0.05 < p ≤ 0.1)

Using multiple meta-regression, the mean duration of illness showed a trend towards explaining this residual heterogeneity ( p = 0.0799, I 2 = 30.6%), whereas CPZ scores did not ( p = 0.2035) (see Supplementary Fig. 22 for bubble plot; Supplementary Table 13A, B for results).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.