HLA Associations Differ by Ethnicity and Aquaporin-4 Antibody Status in Patients With Neuromyelitis Optica Spectrum Disorders.

Neurol Neuroimmunol Neuroinflamm · 2026 · PMC13088193 · PMID 41990286

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barely missed significanceno p-value reported

35 An increased frequency of HLA-DQA1*04:01:02 in Black AQP4-IgG+ patients with NMOSD barely missed significance and re-analysis of this association in larger cohorts, which was not possible in this study because of lack of data on HLA-DQA1 in the NMDP controls, might be warranted.

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did not reach statistical significanceno p-value reported

The HLA-DQB1*03:19:01 allele that is in linkage disequilibrium with DRB1*08:04:01 in individuals with African ancestry was also more common in Black AQP4-IgG+ patients with NMOSD than in controls but did not reach statistical significance after correction for multiple testing.

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