Integrated single-cell and spatial transcriptomic analysis reveals mCAF-SPP1⁺ macrophage-T cell crosstalk shaping immunosuppressive niches in colorectal cancer liver metastasis.

J Transl Med · 2026 · PMC13088502 · PMID 41807965

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a clear trendno p-value reported

At an effector-to-target ratio (E: T) of 1:2 for 48 h, SPP1 showed a clear trend of increasing residual tumour cells.

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