Primary cilia regulate GLP-1 signaling in pancreatic β cells.

Mol Metab · 2026 · PMC13089038 · PMID 41895439

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Consistent with this, we show that cilia enrich for ACs, and direct measurement of ciliary PKA activity in pilot experiments showed a trend toward increase with liraglutide stimulation, while targeted inhibition of ciliary PKA selectively blunted incretin-potentiated secretion – findings that, while preliminary, support a role for cilia-derived signals in amplifying GLP-1 responses.

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