The Effects of Different Doses of Nalbuphine and Esketamine on Prevention of Emergence Agitation in Preschool Children Undergoing Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial.

Drug Des Devel Ther · 2026 · PMC13089463 · PMID 42007395

Europe PMC DOI

hedged sentences

0.0020

closest p · 0.0× alpha

0.3540

boldest claim

The sentences

highly significantP = 0.002actually significant

RM-ANOVA for heart rate demonstrated a highly significant main effect of group ( F = 6.674, P = 0.002), but no significant main effect of time ( P = 0.695) or group-by-time interaction ( P = 0.883).

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did not reach statistical significanceP = 0.354not close (p > 0.1)

Although the incidence in Group N1 was lower than in Group E, this difference did not reach statistical significance after adjustment for multiple comparisons (unadjusted RR = 0.54; 95% CI: 0.25 to 1.18; Bonferroni-adjusted P = 0.354).

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