Metabolomic signatures suggest altered bile acid and energy metabolism in CRB1- retinopathies.

(see Table 1 ) Global metabolite differences between CRB1 patients and controls Of 872 identified compounds detected in the CRB1 group plasma and control group, 141 showed significant elevation and 103 showed significant reduction in CRB1 patients ( p ≤ 0.05), with an additional 62 compounds approaching significance (0.05 < p < 0.10) (42 elevated, 20 reduced) (Fig. 2 ).

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FC values with p ≤ 0.05 and q ≤ 0.10 were considered statistically significant, while FC values with 0.05 < p < 0.10 were considered as trending toward significance Welch’s two-sample t-test was used.

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