Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation.

Nat Commun · 2026 · PMC13090337 · PMID 41991526

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

FIX:C levels were also elevated in c.364 G > A mice treated with SaCas9-NNG-ABE8e relative to those treated with SaCas9-ABE8e, although this difference did not reach statistical significance (Fig. 3e ).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.