A randomized clinical study comparing trabectedin combined with regional hyperthermia with trabectedin in patients with advanced soft tissue sarcoma: HyperTET, a German Interdisciplinary Sarcoma Group trial.

ESMO Open · 2026 · PMC13091197 · PMID 41962307

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a notable trendno p-value reported

did not reach statistical significanceno p-value reported

A notable trend favoring the Tr + RHT arm was seen in patients ( n = 39) who received five or more cycles, although this did not reach statistical significance (HR 0.60, 95% CI 0.30-1.18) ( Supplementary Figure S1 , available at https://doi.org/10.1016/j.esmoop.2026.106921 ).

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