Empagliflozin modulates microRNA expression in human primary cardiomyocytes under CoCl<sub>2</sub>-induced hypoxia.

Although not statistically significant, expression of miR-145-5p showed a decreasing trend after 24 h of exposure to cobalt (p = 0.075) and to the combined treatment of cobalt and Empagliflozin (p = 0.064), compared to untreated cells ( Fig. 3 ).

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Although the differences did not reach statistical significance, increasing the number of biological replicates could potentially render them significant, thereby helping to guide other researchers in identifying relevant miRNAs for further investigation.

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