A systematic review and meta-analysis of non-arsenical adulticide protocols using moxidectin and doxycycline for the treatment of adult heartworm infection in dogs.

Curr Res Parasitol Vector Borne Dis · 2026 · PMC13091312 · PMID 42007372

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0.0800

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did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)

The pooled MD indicated a reduction in worm burden in the Moxi-Doxy group (MD = −6.41, 95% CI: 13.52 to 0.69; I 2 = 98.28%; CoE: low), although this difference did not reach statistical significance ( P = 0.08) ( Fig. 4 ). 3.6.

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