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Differences in Responses to Neoadjuvant Anti-HER2 Therapy between HER2 2+/ISH+ and HER2 3+ in HER2-Positive Breast Cancer.

Cancer Res Treat · 2026 · PMC13093035 · PMID 40259803

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showed a trendno p-value reported
Stratified analysis of HER2 IHC classes showed a trend toward shorter DFS in the HER2 2+/ISH+ group than in the HER2 IHC 3+ group (estimated 5-year DFS, 83.6% vs. 90.6%), although the difference was not significant (p=0.222) ( Fig. 3 ).

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