A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations.

J Neurochem · 2026 · PMC13093242 · PMID 42003427

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0.0190

closest p · 0.4× alpha

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boldest claim

The sentences

nominally significantp = 0.019actually significant

With respect to the phospholipids, the effect of group was nominally significant for PtdSer C20:3n‐6 relative percentage ( p = 0.019) and the TL C20:3n‐6 relative percentage ( p = 0.0087), but did not retain significance upon correction for multiple comparisons (Figure S4 ).

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an overall trendno p-value reported

In contrast, phospholipids showed pronounced age effects that differed by fraction, with an overall trend of monounsaturated FAs increasing and long‐chain omega‐6 polyunsaturated FAs decreasing with age.

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did not quite reach significanceno p-value reported

In UF, the changes observed in this subset of the cohort ( n = 70) are similar to those observed in the full cohort (excluding those for C22:5n‐3 and omega‐6/omega‐3 ratio which did not quite reach significance) and are not reflective of overall lower ChoGpl content.

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